abstract：:Coefficient of kinetic friction (μ) between rabbit visceral and parietal pleura, sliding in vitro at physiological velocities and load, increases markedly after blotting mesothelial surface with filter paper; this increase is only partially reduced by wetting blotted mesothelium with Ringer solution. Given that mesoth...

journal_title：Respiratory physiology & neurobiology

authors： Bodega F,Pecchiari M,Sironi C,Porta C,Arnaboldi F,Barajon I,Agostoni E

更新日期：2012-01-15 00:00:00

abstract：UNLABELLED:We searched for pre-junctional inhibitory muscarinic receptors in isolated bovine trachealis strips and bronchial rings. Electric stimulation (ES)-induced tritiated acetylcholine ([(3)H]-ACh)-release and isometric contractions were determined in muscles incubated with the non-selective muscarinic agonist pil...

journal_title：Respiratory physiology & neurobiology

authors： Baroffio M,Crimi E,Brichetto L,Zappi L,Rehder K,Brusasco V

更新日期：2012-01-15 00:00:00

abstract：:Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interact positively to physiopathologically remodel pulmonary circulation. In present study we have exposed guinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O(2), 15 days; CH) alone or i...

journal_title：Respiratory physiology & neurobiology

authors： Olea E,Ferrer E,Prieto-Lloret J,Gonzalez-Martin C,Vega-Agapito V,Gonzalez-Obeso E,Agapito T,Peinado V,Obeso A,Barbera JA,Gonzalez C

更新日期：2011-12-15 00:00:00

abstract：:Phrenic motoneurons are located in the cervical spinal cord and innervate the diaphragm muscle, the main inspiratory muscle in mammals. Similar to other skeletal muscles, phrenic motoneurons and diaphragm muscle fibers form motor units which are the final element of neuromotor control. In addition to their role in sus...

journal_title：Respiratory physiology & neurobiology

authors： Mantilla CB,Sieck GC

更新日期：2011-10-15 00:00:00

abstract：:The abdominal muscles form part of the expiratory pump in cooperation with the other expiratory muscles, primarily the internal intercostal and triangularis sterni muscles. The discharge of abdominal muscles is divided into four main patterns: augmenting, plateau, spindle and decrementing. The patterns tend to be spec...

journal_title：Respiratory physiology & neurobiology

authors： Iizuka M

更新日期：2011-10-15 00:00:00

abstract：:Many lung and central nervous system disorders require robust and appropriate physiological responses to assure adequate breathing. Factors undermining the efficacy of ventilatory control will diminish the ability to compensate for pathology, threatening life itself. Although most of these same disorders are associate...

journal_title：Respiratory physiology & neurobiology

authors： Huxtable AG,Vinit S,Windelborn JA,Crader SM,Guenther CH,Watters JJ,Mitchell GS

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q(aw)) in a group of heart failure (HF) and control subjects. METHODS:Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF=27±6%, age=65±9 yr) and 12 age-...

journal_title：Respiratory physiology & neurobiology

authors： Ceridon ML,Morris NR,Olson TP,Lalande S,Johnson BD

更新日期：2011-09-15 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene which is a Cl- channel and a regulator of the epithelial Na+ channel (ENaC). We have recently shown that newborn CFTR-deficient mice exhibit abnormalities of the tracheal cartilage leading to altered vent...

journal_title：Respiratory physiology & neurobiology

authors： Bonora M,Riffault L,Marie S,Mall M,Clement A,Tabary O

更新日期：2011-09-15 00:00:00

abstract：:During embryonic development, blood flow is needed not only to nourish the developing embryo but is also important for shaping the vascular network such that it becomes hemodynamically efficient. The first blood vessels form a network called the capillary plexus. After the onset of blood flow, the capillary plexus rem...

journal_title：Respiratory physiology & neurobiology

authors： Jones EA

更新日期：2011-08-31 00:00:00

abstract：:During embryonic development of homeothermic animals like birds and mammals transition from ectothermy to endothermy occurs especially in precocial species of both taxa. Based on some evolutionary aspects of the development of endothermy the review focuses on the prenatal development of endothermy and of the thermoreg...

journal_title：Respiratory physiology & neurobiology

authors： Tzschentke B,Rumpf M

更新日期：2011-08-31 00:00:00

abstract：:Pulmonary surfactant fulfils diverse functions at the lung air-liquid interface of all air-breathing vertebrates. Neurohormonal regulation of surfactant synthesis and secretion is highly conserved among non-mammalian amniotes. Although the pattern of surfactant lipid maturation is similar among species, the onset and ...

journal_title：Respiratory physiology & neurobiology

authors： Orgeig S,Morrison JL,Daniels CB

更新日期：2011-08-31 00:00:00

abstract：:Embryo-environment interactions affecting cardio-respiratory development in vertebrates have been extensively studied, but an equally extensive conceptual framework for interpreting and interrelating these developmental events has lagged behind. In this review, we consider the conceptual constructs of "developmental p...

journal_title：Respiratory physiology & neurobiology

authors： Burggren WW,Reyna KS

更新日期：2011-08-31 00:00:00

abstract：:The C57/BL6 (B6) mouse strain exhibits post-hypoxic frequency decline and periodic breathing, as well as greater amount of irregular breathing during rest in comparison to the A/J and to the B6a1, a chromosomal substitution strain whereby the A/J chromosome 1 is bred onto the B6 background (Han et al., 2002; Yamauchi ...

journal_title：Respiratory physiology & neurobiology

authors： Chai S,Gillombardo CB,Donovan L,Strohl KP

更新日期：2011-08-15 00:00:00

abstract：:Changes in airway temperature can result in respiratory responses such as cough, bronchoconstriction and mucosal secretion after cold exposure and hyperventilation after heat exposure. In the present investigation, we examined the activity of bronchopulmonary receptors in response to activators of thermo-sensitive tra...

journal_title：Respiratory physiology & neurobiology

authors： Zhou Y,Sun B,Li Q,Luo P,Dong L,Rong W

更新日期：2011-08-15 00:00:00

abstract：:Although dyspnoea has been shown to attenuate pain, whether different forms of dyspnoea exert a similar inhibitory effect on pain has never been tested. We examined the effects of two different forms of dyspnoea, i.e., "air hunger" sensation (AIR HUNGER) and "work/effort" sensation (WORK/EFFORT), on pain induced by a ...

journal_title：Respiratory physiology & neurobiology

authors： Yashiro E,Nozaki-Taguchi N,Isono S,Nishino T

更新日期：2011-08-15 00:00:00

abstract：:Cigarette smoke (CS)-induced emphysema is caused by a continuous inflammatory response in the lower respiratory tract. The development of the condition is believed to be mediated by oxidant-antioxidant imbalance. This paper describes the effects of long-term CS exposure on alveolar cell recruitment, antioxidant defens...

journal_title：Respiratory physiology & neurobiology

authors： Bezerra FS,Valença SS,Pires KM,Lanzetti M,Pimenta WA,Schmidt AC,Porto LC,Zin WA

更新日期：2011-07-31 00:00:00

abstract：:We investigated the effects of salbutamol on the markers of epithelial function in a murine model of chronic allergic pulmonary inflammation by recording the ciliary beat frequency (CBF) and the transepithelial potential difference (PD) in vivo. Mice were sensitized and received four challenges of ovalbumin (OVA group...

journal_title：Respiratory physiology & neurobiology

authors： Toledo AC,Arantes-Costa FM,Macchione M,Saldiva PH,Negri EM,Lorenzi-Filho G,Martins MA

更新日期：2011-07-31 00:00:00

abstract：:We hypothesized that hypocapnia is responsible for increased expiratory resistance during NREM sleep. Hypocapnia was induced by hypoxic hyperventilation in 21 subjects (aged 29.4 ± 7.8 yrs, 10 women, BMI 24.4 ± 4.3 kg/m(2)). Isocapnic hypoxia was induced in 12 subjects of whom, 6 underwent hypocapnic hypoxia in the sa...

journal_title：Respiratory physiology & neurobiology

authors： Sankri-Tarbichi AG,Richardson NN,Chowdhuri S,Rowley JA,Safwan Badr M

更新日期：2011-07-31 00:00:00

abstract：:The acid-base balance of arterial blood is important for the clinical management of seriously ill patients, especially patients with acute lung injury or acute respiratory distress syndrome. We developed a novel fluorosensor for continuous blood pH monitoring and evaluated its performance both in vitro and in vivo in ...

journal_title：Respiratory physiology & neurobiology

authors： Jin W,Jiang J,Wang X,Zhu X,Wang G,Song Y,Bai C

更新日期：2011-07-31 00:00:00

abstract：:In Wild Type (WT) and serotonin transporter (5HTT) null mice, we studied oxygen consumption, ventilation and heart rate in air and 5% CO(2) at postnatal (P) days P5, P15, and P25 using either a head-out (younger mice) or whole body plethysmograph (older mice). Body weight and temperature did not differ between the gro...

journal_title：Respiratory physiology & neurobiology

authors： Penatti E,Barina A,Schram K,Li A,Nattie E

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Aquaporin 5 (AQP5) is widely expressed in various organ and tissues. In light of the novel oncogenic properties of aquaporins (AQPs), here we investigated the effect of AQP5 knockdown by RNAi on transmembrane osmotic water permeability, cell migration potential and cell volume regulation ability. METHODS:AQ...

journal_title：Respiratory physiology & neurobiology

authors： Chen Z,Zhang Z,Gu Y,Bai C

更新日期：2011-05-31 00:00:00

abstract：:Embolus occlusion of pulmonary arteries can result in elevated pulmonary blood pressures, often resulting in pulmonary hypertension (PH). Experimental observations have shown that small emboli (diameter <170 μm) can have a disproportionate effect on pulmonary vascular resistance (PVR) compared with larger emboli for t...

journal_title：Respiratory physiology & neurobiology

authors： Clark AR,Burrowes KS,Tawhai MH

更新日期：2011-03-15 00:00:00

abstract：:The retrotrapezoid nucleus (RTN), located at the ventral surface of the medulla oblongata, contains glutamatergic Phox2b-expressing interneurons that have central respiratory chemoreceptor properties. RTN also operates as a relay for hypothalamic pathways that regulate breathing, one of which probably originates from ...

journal_title：Respiratory physiology & neurobiology

authors： Lazarenko RM,Stornetta RL,Bayliss DA,Guyenet PG

更新日期：2011-02-15 00:00:00

abstract：:China had taken strict measures for pandemic 2009 H1N1 infection with enhanced surveillance and hospital isolation since April 2009. In Shenzhen, over 1200 confirmed cases of H1N1 infection were identified. Three young patients died of severe pneumonia. Among them, two boys developed neurological complications. Cytoki...

journal_title：Respiratory physiology & neurobiology

authors： Cheng XW,Lu J,Wu CL,Yi LN,Xie X,Shi XD,Fang SS,Zan H,Kung HF,He ML

更新日期：2011-01-31 00:00:00

abstract：:In recent years, it has become evident that reactive oxygen species (ROS) play a critical role in the regulation of several physiological and pathophysiological processes. Herein we review the main sources, targets and pathophysiological roles of ROS in pulmonary vascular smooth muscle. Mitochondria and NADPH oxidases...

journal_title：Respiratory physiology & neurobiology

authors： Perez-Vizcaino F,Cogolludo A,Moreno L

更新日期：2010-12-31 00:00:00

abstract：:Respiratory sinus arrhythmia (RSA) is the beat-to-beat fluctuation in heart rate at the frequency of the respiratory cycle. While it is common to study RSA under conditions of controlled breathing, where respiratory frequency, and sometimes tidal volume and inspiratory:expiratory ratio are controlled, the effect of co...

journal_title：Respiratory physiology & neurobiology

authors： Larsen PD,Tzeng YC,Sin PY,Galletly DC

更新日期：2010-11-30 00:00:00

abstract：:The locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ...

journal_title：Respiratory physiology & neurobiology

authors： Gargaglioni LH,Hartzler LK,Putnam RW

更新日期：2010-10-31 00:00:00

abstract：:The South American lungfish (Lepidosiren paradoxa) has an arterial P(O(2)) (Pa(O(2))) as high as 70-100 mmHg, corresponding to Hb-O(2) saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R-L) shunt. In hyperoxia (50% O(2)), we studied animals in: (1) aerated water combined with aerial...

journal_title：Respiratory physiology & neurobiology

authors： Bassi M,Giusti H,da Silva GS,Amin-Naves J,Glass ML

更新日期：2010-08-31 00:00:00

abstract：:Using in vitro newborn rat brainstem-spinal cord preparations with and without the parafacial respiratory group (pFRG), we examined the effects of the volatile anaesthetic sevoflurane on the respiratory rhythm oscillators of the pFRG and the preBötzinger complex (preBötC). Our study indicated that sevoflurane depresse...

journal_title：Respiratory physiology & neurobiology

authors： Takita K,Morimoto Y

更新日期：2010-08-31 00:00:00

abstract：:Acetylcholine and ATP appear to mediate excitatory transmission between receptor (glomus) cells and the petrosal ganglion (PG) neuron terminals in the carotid body. In most species these putative transmitters are excitatory, while inhibitory effects had been reported in the rabbit. We studied the effects of the applic...

journal_title：Respiratory physiology & neurobiology

authors： Soto CR,Ortiz FC,Vargas RV,Arroyo J,Alcayaga J

更新日期：2010-07-31 00:00:00

abstract：:Recent studies in vivo and in vitro suggest that both respiratory rhythmogenesis and its central chemosensory modulation arise from multiple, mechanistically and/or anatomically distinct networks whose outputs are similar. These observations are consistent with degeneracy, defined as the ability of structurally distin...

journal_title：Respiratory physiology & neurobiology

authors： Mellen NM

更新日期：2010-06-30 00:00:00

abstract：:The fetal respiratory response to acute hypoxia is characterized by depression, often to apnea. This study examined the effect of hypoxia on the electromyogram (EMG) of the thyroarytenoid (TA) muscle. Under anesthesia catheters were placed in the fetal sheep carotid artery, fourth cerebral ventricle, trachea and amnio...

journal_title：Respiratory physiology & neurobiology

authors： Bissonnette JM,Hohimer AR,Knopp SJ

更新日期：2010-04-30 00:00:00

abstract：:These experiments were designed to determine the effects of EEG state on the response of rats to intermittent hypoxia and to test the hypotheses that short-term potentiation (STP) and ventilatory long term facilitation (vLTF) are state dependent; and that neurons with NMDA receptors in the dorso-ventral pontine respir...

journal_title：Respiratory physiology & neurobiology

authors： Boon JA,Milsom WK

更新日期：2010-04-30 00:00:00

abstract：:The comparatively low compliance of the mammalian lung results in an evolutionary dilemma: the origin and evolution of this bronchoalveolar lung into a high-performance gas-exchange organ results in a high work of breathing that cannot be achieved without the coupled evolution of a muscular diaphragm. However, despite...

journal_title：Respiratory physiology & neurobiology

authors： Perry SF,Similowski T,Klein W,Codd JR

更新日期：2010-04-15 00:00:00

abstract：:This paper presents a modelling framework in which the local stress environment of airway smooth muscle (ASM) cells may be predicted and cellular responses to local stress may be investigated. We consider an elastic axisymmetric model of a layer of connective tissue and circumferential ASM fibres embedded in parenchym...

journal_title：Respiratory physiology & neurobiology

authors： Brook BS,Peel SE,Hall IP,Politi AZ,Sneyd J,Bai Y,Sanderson MJ,Jensen OE

更新日期：2010-01-31 00:00:00

abstract：:Cervical spinal cord injury results in significant functional impairment. It is important to understand the neuroplasticity in response to inactivity of respiratory muscles in order to prevent any associated effects that limit functional recovery. Recent studies have examined the mechanisms involved in inactivity-indu...

journal_title：Respiratory physiology & neurobiology

authors： Mantilla CB,Sieck GC

更新日期：2009-11-30 00:00:00

abstract：:Individuals with spinal cord injury (SCI) commonly complain about difficulty in sleeping. Although various sleep disordered breathing definitions and indices are used that make comparisons between studies difficult, it seems evident that the frequency of sleep disorders is higher in individuals with SCI, especially wi...

journal_title：Respiratory physiology & neurobiology

authors： Biering-Sørensen F,Jennum P,Laub M

更新日期：2009-11-30 00:00:00

abstract：:This review will focus on neural plasticity and recovery of respiratory function after spinal cord injury and feature the "crossed phrenic phenomenon" (CPP) as a model for demonstrating such plasticity and recovery. A very brief summary of the earlier literature on the CPP will be followed by a more detailed review of...

journal_title：Respiratory physiology & neurobiology

authors： Goshgarian HG

更新日期：2009-11-30 00:00:00

abstract：:We examined whether recruitment maneuvers (RMs) with gradual increase in airway pressure (RAMP) provide better outcome than continuous positive airway pressure (CPAP) in paraquat-induced acute lung injury (ALI). Wistar rats received saline intraperitoneally (0.5 mL, CTRL) or paraquat (15 mg/kg, ALI). Twenty-four hours...

journal_title：Respiratory physiology & neurobiology

authors： Riva DR,Contador RS,Baez-Garcia CS,Xisto DG,Cagido VR,Martini SV,Morales MM,Rocco PR,Faffe DS,Zin WA

更新日期：2009-10-31 00:00:00

abstract：:The relationship among airway responsiveness, inflammation and remodelling in asthma is incompletely understood. To investigate potential mechanistic associations, allergen-induced asthma was studied in C57Bl/6 mice. Mice were sensitized and challenged with ovalbumin (OVA) using sub-acute (SA) or chronic (C) protocols...

journal_title：Respiratory physiology & neurobiology

authors： Pinelli V,Marchica CL,Ludwig MS

更新日期：2009-10-31 00:00:00